Herapeutic effect of wet compress of magnesium sulfate combined with vitamin B12 on chemotherapy-induced phlebitis in rabbits

Objective: This study aimed to observe the therapeutic effect of wet compress of magnesium sulfate combined with vitamin B12 on doxorubicin hydrochloride-induced phlebitis in rabbits. Methods: Doxorubicin hydrochloride (0.2%, each side with 5 ml) was injected within 6 min through bilateral auricular veins to build phlebitic models in 48 rabbits. Forty eight hours later, the 48 rabbits were randomly divided into 4 groups (each group with 12 rabbits). 50% magnesium sulfate (Group A), vitamin B12 dissolved in 50% glucose (Group B), 50% magnesium sulfate combined with vitamin B12 dissolved in 50% glucose (Group C) were respectively applied to the bilateral auricular veins twice a day for a week. Rabbits in group D did not receive any treatments. Therapeutic effects were observed in all rabbits a week after treatment. Results: The effective rate was 75% in Group A, 83.33% in Group B, 91.67% in Group C and 16.67% in Group D, respectively. The effective rate was significantly higher in Group C than in Groups A, B and D (all P < 0.05). Conclusion: Vitamin B12 dissolved in 50% glucose combined with 50% magnesium sulfate can significantly improve the therapeutic effect on doxorubicin hydrochloride-induced phlebitis.